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Synthesis, Characterization And Anti-Fungal Activity Of Isatin Schiff Base Derivatives

Author:

Justin Ebuka Ezekwem, Visagaperumal, D. and Vineeth Chandy

Subject Area:

Life Sciences

Abstract:

Isat-2-one was reacted with 4-amino acetanilide in the presence of glacial acetic acid and ethanol. Water molecule was eliminated to form Isatin Schiff base. The obtained Isatin Schiff bases, on reaction with multiple benzaldehyde derivatives in the presence of ethanol and potassium hydroxide formed various products of chalcone derivatives. The obtained compounds (C1-C7) were analysed using H+ NMR, IR, Mass spectroscopy and elemental analysis data and were found to match with the given structures. The synthesized compounds were evaluated for their in vitro anti-fungi activity by using agar disc diffusion method. Was carried out against 2 fungi at concentration 24, 50 and 100 µg/ml.C1 and C7were found to be the most potent against the fungi.

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