White lesions are selectively frequent in the oral cavity. The prevalence of oral leukoplakia is quite prevalent among such lesions. There are many variants of oral leukoplakia, one of which is oral proliferative verrucous leukoplakia (OPVL), it is a rare clinico-pathological entity which is slow growing, long term progressive lesion, but remains an enigmatic and difficult to define. According to the published case series, OPVL regarded as a disease with aggressive biological behaviours due to its high probability of recurrence and high rate of malignant transformation. This article presents the clinico-pathologic characteristic of verrucous leukoplakia turning into squamous cell carcinoma involving right buccal mucosa and commissural area of a sixty eight years old male patient.