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Uncommon link of acute myocarditis post-covid 19 vaccine (bnt162b2 mrna)

Author: 
Sergio Fasullo, PierPaolo Prestifilippo, Alberto Grillo, Piero Levantino, Giuseppina Leone, Simone Lazzara, Giorgio Maringhini, Filippo Ganci, Sebastiano Scalzo, Mirko Luparelli, Marianna Rubino, Luciano Alibani, Mariangela Santamaria1 and Stefania Davi
Subject Area: 
Health Sciences
Abstract: 

This case report describes a case of acute myocarditis post-vaccination. Patient who received the Covid 19 vaccine. There is evidence in the literature linking vaccines to different auto-immune manifestations. Of late, autoimmune manifestations that appear to be caused by an external adjuvant have been grouped into a complex syndrome referred to as autoimmune/inflammatory syndrome induced by adjuvants (ASIA). He presented to hospital with chest pain, fever and weakness after 4 days from vaccination. Laboratory investigations showed elevated creatine kinase and troponin-I, and extensive cardiac investigations yielded a diagnosis of myocarditis. Adjuvants are elements that induce an inflammatory response. In the case of vaccines, adjuvants increase the antigen-specific immune response, to ultimately improve vaccine immunogenicity. The incidence of myocarditis post vaccination is rare Given the benefits of the vaccine and the rarity of this complication, we do not discourage its routine usage when clinically indicated. However, ongoing surveillance is required to evaluate the occurrence of rare adverse events.

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