Background: An anti mycotic is a substance that kills or inhibits the growth of fungi. Papaya is also known as pawpaw or melon tree. Carica papaya is one of the accepted species in the genus Carica of the family Caricaceae. The fruits are the source of flavoring agent in candies, jellies, ice creams etc. It has protein digesting, antiseptic and antimicrobial properties. C.papaya has been widely used in the treatment of diabetes. Aim: To evaluate the antimycotic activity of Carica papaya extract on Candida albicans. Methodology: The antimycotic activity is carried out by agar well diffusion technique against the fungal pathogens and the zone of inhibition is measured in mm diameter. Result: In the present study, Carica papaya was found to be effective against gram-positive Candida albicans organisms tested.