What is new about induction of labour with oral mifepristone versus oral misoprostol at term

Introduction: Induction of labour implies the artificial initiation of uterine contraction in a quiescent uterus by any method like medical, surgical or combined prior to their spontaneous onset.one of the most common indication for labour induction is prolonged pregnancy, which is associated with many of the fetal complications. present study compares effectiveness and safety of induction of labour with mifepristone and with misoprostol. Aim and objective: To compare the safety and efficacy of oral mifepristone with that of oral misoprostol in induction of labour at term. Materials and methods: This was a comperative study involving 100 women with term gestation, women were divided alternatively into two groups with 50 in each group(group 1 mifepristone 200mg given ,group 2 misoprostol 25mcg was given) .The primary outcome measures were successful vaginal delivery ,induction to delivery interval and secondary outcome measures were failed induction ,mode of delivery, birth weight, meconium stained liquor ,fetal distress ,NICU admission ,primary post partum haemorrhage Results: The mean age of women in group 1 and group 2 was 23.16 and 22.72 years respectively .The mean BMI in both the group was similar (22.63kg/m2 and 22.27 kg/m2) The mean induction to delivery was 31.86 hours in group 1 and in group 2 16.11 hours .this is statistically significant in both groups with favourable and unfavourable cervix(p=.00001) Conclusion: we concluded that oral mifepristone seems as effective as oral misoprostol for induction of labour at term, misoprostol was responsible for meconium stained liquor in most of the cases, which was less with mifepristone, so better neonatal outcomes when compared to misoprostol.