Efficacy and safety of lactulose and polyethylene glycol (peg) combination therapy-relux l manufactured by eskag pharma pvt. ltd., kolkata, india in the management of constipation

Constipation is a prevalent gastrointestinal issue affecting millions worldwide. Polyethylene Glycol (PEG) is commonly prescribed for constipation relief and bowel preparation, with FDA approval for use in individuals aged 17 and older. This article reviews the efficacy and safety of PEG, both as a standalone treatment and in combination with Lactulose. PEG is favored for its minimal side effects, improved tolerance, and effectiveness across various patient populations, including adults, pregnant women, and geriatrics. Combination therapy with Lactulose further enhances the efficacy of PEG, offering improved bowel cleansing, reduced side effects, and better patient compliance. Several clinical trials and studies have demonstrated that Lactulose and PEG together provide superior outcomes in terms of stool frequency, consistency, and overall symptom relief. Additionally, a specific product, Relux L, which combines Lactulose and PEG, manufactured by Eskag Parma Ltd., Kolkata, India, has proven to be an effective option for managing constipation and preparing patients for medical procedures. These findings highlight the role of Lactulose and PEG as key agents in the management of chronic constipation and bowel preparation.