Management of orthodontic cases often requires extraction of permanent teeth. The decision to extract the teeth or not depends upon the arch length tooth material discrepancies, the growth pattern, general profile, and arch asymmetries. Earlier, annon-extraction approach or an approach involving the extraction of all four first premolars was the primary basis of treatment planning in orthodontics. However, an alternative orthodontic treatment modality involving the unilateral extraction of premolar in borderline cases has gained popularity nowadays. The present report describes a case with unilateral placed buccally blocked out canine and crowding in upper and lower arch, for which unilateral asymmetric premolar extractionswere performed to achieve aesthetic and functionally stable occlusion.