Amavata is disease caused by vitiation of Vata by Ama, which is the product of incomplete digestion and metabolism. Agni in Ayurveda includes the digestive processes of gastrointestinal tract as well as the metabolic processes in the tissues. Ama could therefore be produced by flawed digestion in gastrointestinal tract or in the tissues by defective metabolic processes. Ama thus produced is said to circulate and block the vessel of the joints and get deposited there causing inflammation by producing symptoms such as stiffness, swelling, and tenderness in small and big joints, making a person lame. The symptoms of Amavata are identical to rheumatism, which include rheumatoid arthritis and rheumatic fever. It is observed that rheumatism is an autoimmune disorder, which is among the collagen disorders having strong and significant parlance with Amavata. Various drug trials were already carried out on Amavata, yet there is a lacuna in the management of Amavata. Hence, in the present clinical study, 30 patients were selected and kept on ‘Alambushadi Churna. All the patients were investigated for complete blood count, RA titer, ASO titer, CRP titer, urine routine, and microscopic, before and after treatment. The collected data was distributed according to age, sex, and prakruti, and a t-test was applied for the clinical assessment of the subjective and objective parameters of ‘Alambushadi Churna.