Introduction: Nowadays, drug-addiction realizes one of major public health problem because of its treatments' coasts and its health and families' disturbances. The goal of our study is to describe drug-addicted people profiles viewed in Anjanamasina Madagascar Mental Health Care on 2011 to 2015. Methods: It was a retrospective descriptive and transversal study, carried on 01st January 2011 to 31th December 2015 in Anjanamasina Mental Health Care. Patients' files were checked and on which, wereanalysed: gender, old-group, kinds of drugs, works, living regions, surroundings attitudes and self-insight. Our population wasconstituted by all patients received drug-addiction diagnosis in the end of their care. Results: Thirty cases of toxicomania were found. Cases raised between 2011 to 2012 and then its decreased. 98,5% were men and 1,5% women. They had between 14 to 60 years-old. Youth and adulthood were the most concerned. Teenagers between 15 to 19 years-old represented the 36,19% of cases. They took especially cannabis on 56,52% of cases, alcohol on 26,55%, alcohol and cannabis associated on 16,92%. More than half of them were on joblessness. Thirty-five lived on a rainy and productive land. 95,52% had at least one drug-addicted people in their surroundings. 47,5% came from disturbed families with fighting and violence against their parents and their partners. Thirty percent had difficulty on adaptation and 15% had psychiatric co morbidities. Discussions: Our study shows the same cases as on literacy especially the gender, the important young people touched. Cannabis was the most used product such as worldwide report which would due to joblessness and families’ relationship violence. Summary: Understanding information about the profile of drug-addicted people in Anjanamasina Mental Health Care is important to improve prevention and care against toxico mania in Madagascar.