The study was aimed to know water quality from analysis of physico-chemical characteristics of Pavana River, Pune from September 2016 to February 2017. Due to the increase in population and industrialization, there shall be a necessity to understand the present status of Pavana River. The study was also aimed to find strong correlation between two parameters in three seasons. The experiment was carried out for three season i.e. Monsoon, Post-monsoon and Pre-monsoon. The water sample is collected from river as the depth changes. The physicochemical parameters such as pH, DO, COD, BOD, Alkalinity, TDS, TSS, TS, Turbidity, Temperature has been studied during analysis. A correlation study has been carried out among the all possible pairs of 10 physico-chemical parameters of river water quality. All the correlations indicate that different parameters are strongly interrelated to each other. A correlation coefficient and regression provides an excellent tool for calculating of various water quality parameters within reasonable degree of accuracy.