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Designing of captopril control release tablets by using different drug to polymers ratio

Author: 
Syed Muhammad Younas, Ghulam Razaque, Noman Ul Haq, Nisar Ahmed Shahwani, Muhammad Arsalan, Ghulam Mustafa Shahwani, Abdullah, Raseed Ahmed and Waheed Ahmed Shah
Subject Area: 
Health Sciences
Abstract: 

The aim of Controlled drug release system is to achieve a delivery profile that result in a high blood level of the drug for a long period of time, while in a conventional drug delivery system the drug level in blood flow rises after each administration of the drug and then falls before the next administration. Different drug to polymer ratios were combined and formulated CR captopril. F1, F2, F3 F4, F3, F5 and F6 prepared six separate formulations and tested their physicochemical properties. Preformulation studies Hausner’s ratio, compressibility index, solubility studies and post formulation studies Hardness, thickness, weight variation, friability, disintegration and dissolution test were conducted. The flow properties were found to be within acceptable limits. The solubility studies done by using different solvents with different temperatures (pH 6.8, 7.4 with 250,370 and 400) it was found with near to the standards. The results of Physical tests were done and found within the acceptable limits. The dissolution of all formulations were checked according to the standard procedure and it was found that all the formulations were acceptable range. It is concluded that the formulations developed of controlled released captopril by using combination of polymers Eudragit, Xanthan Gum and formulation of controlled released of tablets were analyzed. The physical characteristics of tablets were checked accordingly which were within the limits specified. The dissolution of all formulations controlled released captopril showed more than 100% released within specified time. So it is recommended that in future control released tablets of different others drugs may be formulated in same combination of polymers to enhance the patient compliance.

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