Detection of bombay phenotype and transfusion challenges in blood banking

Background: Blood transfusion is an essential part of modern health care. Used correctly, it can save life and improve health. However, the detection and transfusion challenges in Bombay phenotype have focused particular attention. Objective: To investigate meticulously the serological characteristics and secretor status of Bombay phenotype and transfusion management in patients. Setting and Design: This was a descriptive study carried outat a tertiary care hospital in Belgavi, Karnataka over a period of 6 years. Methods: A total of 27, 4361 samples including donors and patientswere tested for blood grouping. To confirm the Bombay phenotype, anti-H lectin was used in forward grouping followed by Adsorption Elution Technique. Results: Eleven Bombay phenotypes in 27, 4361 (0.004%) were detected in the entire study, and out of them six were patients who required blood transfusion and remaining five were donors. Conclusion: This study shows the prevalence of Bombay phenotypeassociated with consanguineous marriage, an important risk factor in southern India. The therapeutic challenges arethe arrangement of compatible blood units and management by alternate techniques.