Advances in dentistry, as well as the increased desire of patients to maintain their dentition, have lead to treatment of teeth that once would have been extracted. Platelet-Rich Fibrin (PRF) is an autologous biologic material created by centrifugation of blood. Choukroun and his associates were amongst the pioneers for using PRF protocol in oral and maxillofacial surgery to improve bone healing in implant dentistry. Autologous PRF is considered to be a healing biomaterial and presently, studies have shown its application in various disciplines of dentistry. Advantages of PRF alone include less surgical time, elimination of techniques and potential healing difficulties associated with membranes, and less resorption during healing, as compared to guided bone regeneration procedures. Hemisection of a mandibular molar may be a suitable treatment option when the decay or resorption is restricted to one root and the other root is healthy. This article describes a simple procedure for hemisection in mandibular molar by vertical cut method, followed by faster regeneration of bone using PRF and bone graft and its subsequent restoration. Hemisection along with latest regenerative protocols and prosthetic rehabilitation yielded a satisfactory result.