Prostate cancer (PC) is the most common type of cancer in men and constitutes a major public health issue. This study examined the effect of a church-based intervention to promote informed decision making for prostate cancer screening among men attending Saint Mary’s Catholic Church, Enugu, Nigeria. A quasi-experimental one group pretest-posttest design was adopted for the study. The participants comprised of 50 men 40-70 years attending Saint Mary’s Catholic Church, Enugu. A researcher developed questionnaire was the instrument used for data collection pre and post intervention. Statistical analysis for association was performed using ANOVA. Result revealed that mean age of the participants was 54+12.9 years. Majority 36(72%) had not heard of prostate cancer at pre-intervention versus 50(100%) at post-intervention (p < 0.05) Few 15(30%) of the participants were aware of screening tests for prostate cancer at pre intervention versus 50 (100%) at post intervention. It was recommended that initiation of cancer teachings in churches and public places should be intensified. There should be free screening for prostate cancer for all men.