Objective: To discuss the effect of systemic nursing on postoperative recovery of gastric cancer patients. Methods: According to the patient's operation time, 134 patients with radical gastrectomy from January 2016 to July 2018 were randomly divided into two groups, 64 in each group. Patients in the control group received routine care and the observation group received systematic nursing intervention based on routine care. The recovery and complications of the two groups were compared. Results: In the observation group, the first anesthesia time, the first time to the ground, and the total hospital stay were shorter than the control group, and the incidence of complications was lower than that of the control group (P<0.05). Conclusion: Systematic nursing intervention in patients with gastric cancer can significantly shorten the recovery time after radical gastrectomy in patients, and significantly reduce the incidence of complications in patients with gastric cancer.