Background: There are many treatments given for anterior cruciate ligament sprain which includes Anti-inflammatory Drugs, ultra sound therapy, cyrotherapy however, studies involving taping technique for management of anterior cruciate ligament sprain are limited to this date. Objective: To find outeffect of taping technique for anterior cruciate ligament sprain of knee joint. Study design: Quasi experimental study design. Subjects: 30 subjects with anterior cruciate ligament sprain age group 20-40 years of males. Intervention: 15subjects in the Group A received taping technique with conventional therapy pre and post-test and 15 subjects in Group B received Conventional Physical therapy with pre and post-test. Outcome measure: Numeric pain rating scale, Anterior Cruciate Ligament Quality Of Life Questionnaire. Results: Statistical analysis was done by using Paired‘t’ test which showed significant improvement in both group. Conclusion: taping technique with conventional therapy has significant result in the reduction of pain and functional activity in patients with anterior cruciate ligament sprain.