The present randomized controlled trial study was carried out over a period of one year to observe the effects of perioperative parenteral nutrition on weight, Serum albumin and total lymphocyte count. Hundred patients, admitted and operated were randomly divided into two groups of 50 each. Group A (Study group) and group B (Control group). Group A patients were given perioperative parenteral nutritional support whereas patients in the control group received no such treatment. Statistically significant increase in total serum albumin (P<0.001) was found in the study group. Total leucocyte count and weight was also better in the study group but it was not statistically significant. Parenteral perioperative nutritional support has a vital role in improving weight; serum albumin and total leucocyte count in surgical patients. It should be included in the management of surgical patients if affordable.