Objective: The objective of this study to find out incidence of surgical site infection in clean surgeries operated with peri-operative and post-operative dose of antibiotics. Setting and Design: A Prospective study in a tertiary care hospital in eastern India. Durations:one year. Materials and methods: 25 General surgical cases were operated with perioperative 3 doses versus postoperative 5 days course of antibiotic in each group from July 2018 to August 2019. Data collected and analysed and two Sided 'P' Value was compared. Results: Out of two groups 8% and 12% was the incidence of surgical site infection and 'p' value was1.000 which is statistically insignificant. Conclusion: Use of 3 dose perioperative antibiotic is sufficient to prevent surgical site infection and no need of 5 days course of antibiotics.