Volkameria inermis is an evergreen shrub of 3m tall, distributed throughout the tropical and inter tropical regions of India. It belongs to the family Lamiaceae. The petroleum ether, chloroform, ethyl acetate, ethanol and aqueous leaf extracts of Volkameria inermis were screened for free radical scavenging activity against DPPH, superoxide, hydroxyl, hydrogen peroxide and nitric oxide. The scavenging activity was found to be dose dependent. Of all the extracts the ethanolic extract showed maximum scavenging activity. Hence, from the present study it can be concluded that the leaves of Volkameria inermis possess good radical scavenging activity and it can be used as an easily available source of natural antioxidants.