Gross and ultrastructural review of affect of celphos on different human organs

Aluminium phosphide being economical and its ease for availability, extensively used in developing countries as an effective grain fumigant and rodenticide, poses significant toxicity risks to humans, particularly in cases of intentional ingestion for suicidal attempts.After reviewing the electronic and print media and various textbooks we got to know the effect of AlP poisoning on the vital orangs of human body. It affects the gastrointestinal, cardiovascular, respiratory, and nervous systems, with later manifestations of hepatic and renal failure and disseminated intravascular coagulation.This paper explores the ultrastructural and gross pathological effects of aluminum phosphide (AlP) poisoning on various human vital organs,offering valuable insights for medical professionals and researchers in improving treatment protocols and patient outcomes.The study compiles findings from multiple autopsies and histopathological analyses to detail the impact of AlP on the heart, liver, lungs, kidneys, brain, and spleen. The results reveal extensive cellular and tissue damage caused by AlP poisoning, such as myocardial necrosis and rhexis due to hypercontracted sarcomeres, centrizonal necrosis, alveolar thickening, acute tubular necrosis, and dilated and congested sinusoids., which leads to high mortality rates due tomulti-organ failure.It emphasizes the critical need for enhanced clinical management strategies and the development of specific antidotes for AlP poisoning. Thus,this review thoroughly investigates the toxicological effects of AlP poisoning on various human organs, detailing both microscopic and gross pathological alterations.