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Implications of neoadjuvant chemotherapy interruption and subsequent surgical delay on the pathological response in covid 19 positive locally advanced breast cancer NCI, Egypt experience

Author: 
Marwa Mahmoud Selim, Dalia Ibraheem, AmiraIsmailKhater and Heba Gamal
Subject Area: 
Health Sciences
Abstract: 

Introduction: In late December 2019, the first outbreak of COVID 19 appeared in Wuhan, China. The WHO announced the beginning of the pandemic and the COVID 19 as a global health emergency (WHO, 2020). As a result of this serious situation, the health care systems worldwide were overwhelmed by the high number of infected and panic cases resulted in exhaustion of resources. Patients and methods: Medical files for breast cancer patients in our institute under neoadjuvant chemotherapy who proved to be infected with COVID 19 virus from the January 2020 till December 2020 were reviewed. Results: Pathological complete response were seen in 69.0 % of cases (20 patients). Delayed time to CTH either 3weeks or one month didn’t affect PCR (P=0.688). However type of surgery had significant relation to PCR. As 10 out of 11 patients (90.9%) who did BCS achieving PCR (P=0.046). Conclusion: In this study, the interruption of the treatment of the locally advanced breast cancer due to infection by COVID 19 virus had no impact on achieving complete pathological response. The analysis of the temporal delay revealed that the delay from 3 week to one month away from date of next cycle maximum has no impact on pathological response. The type of pathological response may be affected by other clinical and biological factors

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