Objective: To study the incidence of Cardiogenic Shock (CS) in patients with acute myocardial infarction (AMI) Methods: This is single centre prospective analytical observational study. The study was conducted during 21St August 2010 to 20th August 2012 in a tertiary care hospital. This study included 250 patients with AMI. All of the patients included were primary thrombolysed. Results: This analysis pertains to the 25 (10%) patients who unequivocally developed shock after admission. Out of 25 patients who developed shock 13 expired (52%mortality). • 60-65 is the predominant age group to get shock. • 64% of patients were males who developed shock. • 40% and 60% of patients who developed shock had DM and HTN respectively. • 40%of patients who developed shock had history of previous myocardial infarction. • 64% patients who developed shock had smoking as addiction. • Around 68% patients who developed shock were having Anterior wall MI. • 7.76%, 25.6% and 25% belonging to Killip Class I, II and III respectively developed shock. • 48%patients who developed shock had h/0 angina compared to 35.55%in the non-shock group. Conclusion: The incidence of CS was around 10% in ST-segment elevation myocardial infarction (STEMI) in our study. The strongest predictors for development of CS in our study were age, gender, diabetes mellitus, hypertension, previous myocardial infarction, smoking, anterior infarct, higher Killip class, and history of angina. The mortality among patients with CS in our study was 52%.