Objective: To evaluate the influence of moral intelligence and self-efficacy on achievement motivation among Saudi Middle Schools' Gifted Students. Methods: This was a cross sectional study conducted among Saudi middle schools' gifted students in Makkah, Saudi Arabia. The study explored the moral intelligence, self-efficacy and achievement motivation of gifted students using validated and piloted self-administered questionnaires. Simple random sampling technique was used to select 122 out of 733 male gifted students in 89 schools in Makkah, Saudi Arabia. Data was analysed using SPSS. Results: The study included 46, 42, and 34 first, second and third level middle school students respectively. The results indicated that the respondents had moderate score in the self-control (4.225 ± 0.463), tolerance (3.899 ± 0.515), conscience (3.625 ± 0.453), respect (3.666 ± 0.535) and empathy (3.418 ± 0.484) dimensions, whereas fairness (2.665 ± 0.664) and kindness (2.570 ± 0.721) had low mean scores. The students demonstrated moderate levels of self-efficacy and achievement motivation. Regression analysis showed that overall score of moral intelligence (OR: 1.069; 95% CI: 1.039 – 1.100; P < 0.001), and self-efficacy (OR: 1.081; 95% CI: 1.044 – 1.120; P < 0.001) were significant predictors of achievement motivation among the students. There was no significant impact for interactions of moral intelligence dimensions and self-efficacy on achievement motivation. Conclusion: Saudi middle schools' gifted students demonstrated moderate level of self-efficacy; achievement motivation, and moral intelligence. Overall score of moral intelligence and self-efficacy are significant predictors of achievement motivation. Self-efficacy had no moderating influence on achievement motivation among Saudi middle schools' gifted students.