Variation of teeth has been an enduring interest to the clinical practitioner and scientist. One such variation includes amelogenesis imperfecta which is heterogenous inherited disorder that disturbs the developing enamel of both primary and permanent dentition. The result is a dentition which lacks function and esthetics. As Prosthodontists, we aim to change the self-esteem, confidence and possibly the course of life of the patients by functional and esthetic rehabilitation of their dentition. This case report describes a interdisciplinary approach for full mouth rehabilitation of a patient having amelogenesis imperfecta with severe anterior open-bite. This treatment resulted in improved function, esthetics and self-confidence of the patient.