The civilian nuclear enrichment specifically focuses on economic development and technological advancement of the country. The paper raises a central question on the link between the nuclear programme and socio-political transitions in Iran. People of Iran had a significant historical role in determining the socio-political structures of the country. For instance, Islamic revolution of 1979 was resultant in establishing Islam-centric political and social system in the country. This such change would not be a longer solution to protect the interest of the citizens since the political mobility has been set in the very early period after the revolution. Mobilities such as these and subsequent changes have been empowered by the different domestic and external political factors. A new policy variable that was a nuclear programme put forward by the Islamic Iran in 1981 and got support from all the factions irrespective of their difference, and they held on no ambiguity on states’ affairs. New factions’ influence escalated in Iranian politics, notably since the last phase of the 1980s, which laid divisions in the approach of the people towards the nuclear enrichment. Then, it was not only the subject of international players but also the important parameter of domestic political factions in Iran. The article examines the changes in the socio-political spectrums of Iran from the standpoint of the development of the nuclear programme and confrontations. It analyses the dynamic political mobilisations and the impact of the nuclear deal (P5+1) on the socioeconomic profile of the country.