This research aims to identify and analysis of microscopic spermatozoa quality from infertile patient before and after take a supplements from Anadara granosa L. Semen sample were taken from infertile patients at the Prodia Laboratory, Makassar, Indonesia. The clamp sample were collected from Pannikiang Island, District of Barru, South Sulawesi, Indonesia. Data analysis applied T-test in order to know the concentration, motility and viability of sperm quality from infertility patients. The results show that placebo administration of 2 capsule per day significantly improved the microscopic characteristic of the concentration, motility and viability of the sperm.