Nano-in-Medicine is a complex field of exploration with far-reaching technological and medical possibilities. Nanotechnology in diabetes research has facilitated the evolution of novel glucose measurement and insulin delivery systems. Not only is detecting glucose in the food and pharmaceutical industries very important. In addition, glucose monitoring is particularly critical for diabetes supervision. The objective of any kind of diabetes therapy is to reach nearly physiological glucose levels. The current view points toward a continuous insulin infusion by means of insulin pumps. A PID algorithm for blood glucose control is outlined, and the importance of sensor development emphasized. In addition to nanotechnology, the modern information technology has entered the field. Worldwide diabetes research activities at its interface with nanotechnology have created devices at the micro- or nanoscale by which the experimental approach toward an artificial pancreas is already put in practice. In the present paper, some aspects of a three-term control algorithm for glucose are treated, as well as few glucose sensors are set as examples, based on concepts and developments of nanotechnology in the field of diabetes research.