Among them, non-alcoholic steatohepatitis (NASH), consists of a stage of greater severity and is characterized by the presence of hepatic steatosis, hepatocellular ballooning, micro and macro vesicular steatosis, with inflammatory response, and hepatic fibrosis, has emerged as a cause of chronic liver disease that may lead to severe clinical conditions, which include cirrhosis and hepatocellular carcinoma (HCC).Still in the present moment there is no pharmacological treatment for NAFLD and NASH. However, changes related to the lifestyle of these patients appear as an alternative to generate health benefits of these patients, the RPE and diet modification, as the only way to set this disease. Recents studies have demonstrated that the regular practice of physical exercise associated with a macronutrient intake management causes benefits related to weight loss, body mass index, improve of lipogenic imbalance, inflammatory response, and histological profile in patients. However it is not known fully what the role of RPE and diet modification remaining unclear. The objective of this review is to investigate the role non-pharmacological treatment strategiesin path physiological process in NASH.
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