Large periapical lesions are always a challenge for the clinicians. Treatment planning for extensive lesions is a dilema. Literature has documented successful management of large periapical lesions using non-surgical as well as surgical treatment approach. The pros & cons of non-surgical versus surgical treatment modality should be carefully studied for individual case. This case report presents non-surgical resolution of a large periapical lesion of endodontic origin in maxillary anterior teeth using various formulations of calcium hydroxide as intracanal medicament & Nd: Yag Laser as adjuvant method of root canal disinfection.