Fatty liver is a reversible condition in large vacuoles of triglycerides fat accumulates in the liver cells via the process of steatosis. It occurs in two forms, they are Alcoholic fatty liver and Non- alcoholic fatty liver. Alcoholic fatty liver is a condition in which excess fat is stored in the liver due to heavy alchol use. Non alcoholic fatty liver is a condition in which excess fat is stored in the liver This accumulation of fat is not caused by heavy alcoholic use.In this study our main main objective is to assess the efficacy and comparision between vit-E and metadoxine + L –Asparagine. In our study total 110 patients were included.out of 110,55 pa patients were prescribed with Vitamin E AND 55 patients were prescribed with metadoxine +L –Asparagine.To assess the efficacy of two drugs Fishers exact test was used.The drug vitamin E in 55 patients shows the reduced size of liver when compared to Metadoxine +L-Asparagine. Our study concludes that treatment of fatty liver with vitamin E is more effective when compared with treatment of Metadoxine +L-Asparagine.