Background: Invasive fungal infections (IFI) are uncommon, but when they occur, they are devastating to patients. These infections are opportunistic, they occur when the organism to which are frequently exposed gain entry to the body due to a decrease in host defenses. Periodontitis usually caused by bacteria infection. The aim of this study is to introduce a rare case of periodontitis suspected caused by fungal infection. Case: The focus case is 59 year-old immunocompromised patient with left maxillary canine teeth had a caries, vital pulp but there was already swelling on her left cheek, very sharp pain , the patient had a headache, no fever and normal gingiva. Result: The patient was treated with antibiotic, no effect but with antifungal had a good outcome and the left maxillary canine teeth had an endodontic treatment Conclusion: It is suspected that this periodontitis was caused by fungal infection because this patient had a history identification of fungal infection which was cultured from her right ear and the skin swab of ass right.
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