Pharmaceutical design of no release from iron, manganese and ruthenium nitrosyl complexes

This manuscript is an update of some important concerns about nitrosyl complexes having the ability to act as nitric oxide releasing compounds under varied circumstances involving ligand, metal and solution properties. In current times seek for efficient and less harmful NO releasing molecules at desirable target and concentration has gained enormity in nitrosyl chemistry. Iron, ruthenium and manganese nitrosyls have been investigated to a considerable extent to disentangle their electronic transition (excitation) under visible light to act as NO donor without harming healthy cells of a target. There are many evidences supporting the NO-lability to be increased if amino acids are used as complexing ligands, design of reduction centre close to an NO grouping and development of porphyrin system based nitrosyl complexes. From the overall survey it may be concluded that desirable properties of such scaffolds need to be evaluated further to well suit with biological milieu.