Platelet-rich fibrin- second generation platelet concentrate; and its clinical applications – a literature review

Wound healing process involves the activity of leukocytes and platelets. The growth factors present in platelets are important to guide the regenerating cells to the area of healing. After the introduction of regenerative potentiality of platelets in 1974, various platelet concentrates platelet rich plasma (PRP) and platelet rich fibrin (PRF) were used as regenerative medicine preparations. Platelet rich fibrin (PRF) is an autogenous biomaterial consisting of growth factors and cytokines entrapped in a fibrin matrix. It combines the fibrant sealant properties along with growth factors thereby providing an ideal environment for wound healing and regeneration of tissues. PRF is produced with a simple method, low cost and easily available, which has been applied in different fields of dentistry, particularly oral and maxillofacial, orthopaedic and plastic surgery. The following review attempts regarding the technique of using PRF, focusing on its preparation, advantages, and disadvantages of using it in clinical applications.