Systemic redox balance and trace elements in premature hair greying: a cross-sectional study

Background: Premature hair greying (PHG) is a complex phenomenon influenced by various factors. Systemic redox balance plays a crucial role in maintaining hair pigmentation and growth. The present study aimed to investigate systemic redox balance and trace element levels in subjects with PHG and healthy controls. Materials and Methods: This cross-sectional study enrolled 40 PHG patients and 40 healthy controls in the age group 15–25 years after taking voluntary informed consent. 5 ml of venous blood sample was obtained from the subjects and used for the estimation of serum malondialdehyde (MDA), superoxide dismutase (SOD), copper, iron, calcium, and zinc levels. MDA and SOD were estimated by the ELISA method and trace elements and calcium by an automated biochemistry analyzer. Results: The mean levels of MDA and SOD were found to be 1.553±0.58**, 68.90±21.04** in PHG as compared to healthy controls, which were 0.66±0.58, 148.3±16.99, respectively. The elevation of MDA levels and decreased SOD levels in PHG was statistically highly significant (p<0.001). This indicates systemic redox imbalance in PHG subjects. Similarly, the mean values of copper, iron, zinc, and calcium were significantly lowered in PHG subjects in comparison to healthy controls (p<0.001). Conclusion: In conclusion, the intricate dance between trace elements and systemic redox balance plays a pivotal role in maintaining the youthful Vigor of our hair. Premature hair greying, once considered an inevitable fate, is now revealed to be intimately linked to the delicate balance of essential micronutrients and the body's antioxidant defences. The antioxidant arsenal, comprising vitamins C and E, selenium, and other phytochemicals, serves as a formidable bulwark against the ravages of reactive oxygen species.