Vitamin D receptor gene polymorphism in obese and non obese Indian women with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the women in reproductive age group. Accumulating evidences from the recent studies indicate that vitamin D receptor (VDR) genetic variants may influence the development of insulin resistance and so related to the pathogenesis of polycystic ovary syndrome. The aim of the present study was to determine the VDR BsmI gene variant in intron 8 (A/G) (rs1544410) in normal controls, obese PCOS women and non obese PCOS women in India. A total of 225 women aged between 19-36 years participated in the study. The subjects were divided into three groups as obese PCOS women, non obese PCOS women and healthy controls and each group consists of 75 participants. Genotypes of VDR gene in intron 8 (A/G) with BsmI restriction enzyme were determined using the PCR-RFLP method. There was no statistical difference in genotype of AA, GA and GG between PCOS women and control women (p value >0.05). Our study suggests that there was no significant association of BsmI genotypes with both obese and non obese PCOS women.