Primary lateral sclerosis: a rare case report

Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Primary lateral sclerosis (PLS) is characterized by insidious onset of progressive upper motor neuron dysfunction in the absence of clinical signs of lower motor neuron involvement . The course of the disease is insidious and progressive, usually starting with the lower extremities, weakness may progress to affect the arms and the muscles at the base of the brain (bulbar muscles). As a rare disease, diagnosis is exclusionary. We are reporting a case of 46 year old female presented with lower limb weakness since 3 years which progressed to upper limb weakness and spastic dysarthria.