The Immune Features Of Salmonella Typhi Somaic “O” Antigen Induced Lapin Cryoglobulinemia

The present work was aimed at developing an animal model for the delineation of the immune features of the Salmonella typhi associated cryglobulinemia. The elected immune system was the rabbit. The test stimulant was S.typhi O antigen and the specific immune priming protocols were: Two systemic, one mucosal multisite, and one combined systemic-mucosal routs. The attitude was being through the demonstration for the effects of the time duration after the end of priming protocols. S.typhi O antigen can stimulate cryoglobulin responses using systemic, mucosal as well as combined systemic-mucosal routs. As the time duration post to the ends of priming protocols proceeds from 15 to 30 then to 45 days cryoglobulin response increased in terms of concentration, specific cryoglobulin antibody activity for typhoid O antigen as well as the shared human rheumatoid factor antibody acticvity. Bio meteric evaluation for the differences between the different tested priming protocols were non significant. However, such evaluation were significant when were done to the differences, between the time durations between 15,30 and45 days as well as 45 and 15, 30 and 15 and controls. Finally the major immune features of the typhoid lapin cryoglobulin were, cryoprotein, precipitable at 4C, dissolvable at 37C, reprecipitable at 4C and having specific antibody and shared autoantibody activity.