CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Landscape of additional chromosomal abnormalities in philadelphia chromosome positive acute lymphoblastic leukemia: 5year experience of a regional cancer center in south east Asia

Author: 
Shanthala S., Obula Reddy C., Kavitha BL., Padma M., Lokanatha D. and Prasanna Kumari
Subject Area: 
Health Sciences
Abstract: 

Background: Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) is an aggressive disease, which differs from chronic myeloid leukemia in lymphoid blast crisis at both chromosomal and molecular level. The current study aims to study additional chromosomal abnormalities (ACAs) in Ph+ALL, with review on its prognostic implications. Materials and Methods: This is retrospective single group exploratory study, from 2014 to 2019. Cytogenetic information of 74 cases of Ph+ALL and their clinical information were obtained from the departmental records and case files. Cytogenetic analysis of samples was done in accordance with standard laboratory protocol. Results: Thirty out of 74 patients showed ACAs (40.5%). The median age of patients was 21years. ACAs were more frequent in females than in males up to 40years of age and reverse was true in older patients. Most frequent abnormalities observed were extra Ph, del(9p), add(19p), del(6q) and dic(9;12). Limited follow-up data for patients with extra Ph showed complete remission at median survival of 15 months and poor prognosis in an elderly patient with dic(9;12) as additional abnormality. Conclusion: The frequency and pattern of ACAs in our cohort of Ph+ALL patients were similar to standard available literature, with few exceptions. Long-term follow-up studies are recommended to analyze the prognostic significance of these ACAs in Ph+ALL.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran