HIV-related oral conditions occur in a large proportion of patients, and frequently are misdiagnosed or inadequately treated. Dental expertise is necessary for appropriate management of oral manifestations of HIV infection or AIDS, but many patients do not receive adequate dental care. Common or notable HIV-related oral conditions include xerostomia, candidiasis, oral hairy leukoplakia, periodontal diseases such as linear gingival erythema and necrotizing ulcerative periodontitis, Kaposi’s sarcoma, human papilloma virus-associated warts, and ulcerative conditions including herpes simplex virus lesions and recurrent aphthous ulcers. This article summarizes a presentation on oral manifestations of HIV disease and its clinical presentation.