Primary objective of the literature is recognize and evaluate the wide array of oral manifestations associated with red blood cell disorders which would eventually aid in diagnosis of the lesions associated with the disorders for the practitioners. It starts with petechiae, spontaneous gingival bleeding, herpetic infection in aplastic anaemia to hunter’s glossitis in pernicious anaemia. Literature also includes enamel hypoplasia associated with erythroblastis fetalis, atrophic glossitis in iron deficiency anemia with symptom of glossodynia in megaloblastic anemia. Marked manifestations of pharyngo-esophageal ulcerations and esophageal webs seen in plummer Vinson syndrome and periodontitis, taurodontism, agenesia, supernumerary teeth to be seen in fanconi’s anemia. Literature ends with midfacial overgrowth, radiographic dentofacial abnormalities in sickle cell anemia and brodie syndrome, chip munk facies to be seen in thalassemia patients.