Heart is mentioned in many spiritual wisdom traditions. It is said that the heart plays a crucial role in determining our physical reality. In this work, we refer to the heart mentioned in a spiritual context as spiritual heart. We explore the use of quantum physics to explain how and why the spiritual heart determines our physical reality. In our previous work, we demonstrated that everyone and everything is made of matter, energy, and information. We propose to define spirit as the content of information, spiritual heart as the receiver of information, and mind as the processor of information, respectively. We show that these definitions make it possible to use quantum physics to explain spiritual phenomena such as intuition, telepathy, clairvoyance, distant healing, psychokinesis, and more. We can use quantum measurement phenomena to explain the role of spiritual heart plays in determining physical reality, we examine the process of quantum measurement. We show that quantum measurement indicates the role of spiritual heart and mind in determining the physical reality and it reveals the process of manifestation. It shows how our physical reality is determined by our soul, spiritual heart, and mind. This insight suggests again that it is possible to integrate natural science and spirituality together scientifically in one scientific and mathematic framework. This work has great significance in the natural sciences, in social sciences such as politics, economics, philosophy, psychology, consciousness studies, and in religion and in the healing arts.