of trace elements (mg and cu) and dyslipidemia in type 2 diabetes mellitus (t2dm) patients presenting in a tertiary care hospital of South East Asia

Introduction: Diabetes mellitus is a metabolic syndrome, which affect carbohydrates, lipid and protein metabolism. It is a heterogeneous disorder characterized by hyperglycemia due to impaired glucose utilization, resulting from defect in insulin secretion and insulin action. Alteration of some trace elements (mg and cu) has been reported in Diabetes Mellitus. These trace elements might have specific role in the pathogenesis and progress of the disease. Dyslipidaemia was seen in diabetic patients and was primarily responsible for risk of several complications in Type 2 Diabetes Mellitus (T2DM) patients. Materials and Methods: The study was done in the Department of Biochemistry of two teaching medical college and hospitals of India, one in western India and one in North east India. The present study included total 100 subjects, divided into two group in which group 1 (healthy control) having 50 subjects and group 2 (Uncontrolled Diabetes mellitus) having 50 patients, groups were selected randomly without any bias of age, sex, socioeconomic status and duration of disease. Serum Mg estimated by calmagite method and serum Cu estimated by Calorimetric method of semi auto analyzer. Lipid profile was estimated by enzymatic method of semi auto analyzer. Observation and Results: Mg level was found significantly decreased (p<0.001) in serum sample uncontrolled Diabetes mellitus patients compare to healthy subject. Cu level was found significantly increased (p<0.001) in serum of uncontrolled Diabetes mellitus patients compare to healthy subject. Lipid profile were found significantly increased level of total cholesterol (TC), very low density lipoprotein (VLDL), low density lipoprotein (LDL), triacylglycerol (TG) and HDL level was found significantly decreased Discussion and Conclusion: According to our study showed decrease level of Mg and elevated Cu concentration in uncontrolled T2DM patients, and this alteration affect lipoprotein metabolism and caused several abnormalities and greater risk of secondary (cardiovascular and renal diseases) disorders.